The impact of frailty on glycaemic control in older adults with type 1 diabetes: An observational study
Authors' conclusion
While frailty is often associated with hypoglycaemia in diabetes, this was not demonstrated in our type 1 diabetes cohort. Raised HbA1c levels with frailty may reflect recommendations to relax glucose targets. However, no difference was found in %TBR with frailty.
Study context
- Population
- Adults over 65 with T1D confirmed by C-peptide measurement
- Participants
- 83 participants
- Exposure
- Robust vs prefrail vs frail
- Robustn = 38reference
- Prefrailn = 29
- Frailn = 16
- Outcome
- CGM metrics across frailty categories, focusing on %TBR
- Follow-up
- 10 days
Methodological detailsblinded continuous glucose monitors (CGM) (Dexcom G6/G7) worn for 10 days
- Blinded CGM (Dexcom G6/G7) worn for 10 days
Main finding
As reported in the abstract
CGM-derived glycaemic parameters incl. %TBR
- No difference in any CGM-derived glycaemic parameter across the frailty spectrum, regardless of frailty assessment used
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1cFrail vs Robust · frailty associated with higher HbA1c | P = 0.025 |
| MoCA scoreFrail vs Robust · frailty associated with lower MoCA scores | P = < 0.001 |
Original publication
The impact of frailty on glycaemic control in older adults with type 1 diabetes: An observational study. Diabet Med. Published 23 June 2026. doi:10.
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