Extracellular matrix proteins as risk markers for complications in type 1 diabetes
Main finding · Composite kidney endpointResult — go to the resultAdjusted hazard ratio 1.30 95% CI 1.08–1.57Authors' conclusion
Higher baseline serum PRO-C3, a marker of collagen type III formation and fibrogenesis, was associated with an increased risk of developing the composite kidney endpoint and all-cause mortality in individuals with type 1 diabetes.
Study context
- Population
- Individuals with T1D
- Participants
- 662 individuals
- Exposure
- Per 1-SD increase in log2-transformed serum collagen biomarkers
- Outcome
- Composite kidney endpoint
- Follow-up
- Median 6.3 (IQR: 5.9-6.7) years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.30
95% CI 1.08–1.57
P < 0.01
Higher baseline PRO-C3
adjusted HR 1.30 (95% CI 1.08–1.57); P < 0.01
Per 1-SD increase in log2-transformed level, as printed
- Participants experiencing composite kidney endpoint
- 125 of 662
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortalityPer 1-SD increase in log2-transformed level | 1.36 (1.06–1.76) | P = 0.016 | |
| 0.512Adjusted hazard ratio (log scale) |
- All-cause mortality — Participants who died
- 58
Albuminuria progression and CV events (PRO-C3)
- Progressed in albuminuria
- 102
- Developed a CV event
- 94
- No associations between PRO-C3 and albuminuria progression or CV events
PRO-C7, PRO-C28 and CTX-III
- PRO-C7, PRO-C28 and CTX-III not associated with any endpoint
Original publication
Extracellular matrix proteins as risk markers for complications in type 1 diabetes. Diabet Med. Published 20 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →