Longitudinal variability of lipoprotein(a) in youth-onset type 1 diabetes: implications for cardiovascular risk stratification
Authors' conclusion
In youth with type 1 diabetes, Lp(a) is not as stable as previously assumed, exhibiting clinically relevant variability over time. These findings challenge the current paradigm of a single lifetime Lp(a) measurement and suggest that repeated assessment, particularly during adolescence, may improve early cardiovascular risk stratification.
Study context
- Population
- Children and adolescents with T1D attending Geneva University Hospitals, 2012–20231,403 Lp(a) measurements
- Participants
- 286 children
- Outcome
- Intra- and inter-individual trajectories of Lp(a) and implications of Lp(a) variability for cardiovascular risk classification
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Elevated Lp(a) (≥ 300 mg/l) at baseline
26%
Intraindividual fluctuations exceeding 50% of individual maximum value, among participants with serial measurements
32%
Reclassification across the 300 mg/l cardiovascular risk threshold
11.9%
Observational data: associations, not effects.
Further findings
Seasonal variation of Lp(a)
- Modest seasonal variation, higher concentrations in autumn and winter
- P < 0.05
Observation period
- Observation period, median (IQR)
- 6.2 years (2.9-9.6)
- Measurements per participant
- 1 to 13
Original publication
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