The Effect of COVID‐19 on Incident Diabetes in Pediatric Patients: Findings From the National COVID‐19 Cohort Collaborative (N3C)
Main finding · Incident diabetesResult — go to the resultCIR 1.03 95% CI 0.65–1.41Authors' conclusion
COVID-19 was not associated with an increased risk of diabetes in pediatric patients. Incidence rates were highest early in the pandemic, and mirrored patterns of pandemic-era healthcare utilization. The predominance of incident T2D subtype is concerning for the adverse effects of pandemic-related lifestyle changes among pediatric patients.
Study context
- Population
- Pediatric patients, National COVID-19 Cohort Collaborative (N3C) data
- Exposure
- COVID-19-positive vs COVID-19-negative or acute respiratory illness (ARI) controls
- Outcome
- Cumulative incidence ratio (CIR) of incident diabetes for each viral variant era
Methodological detailsweighted on demographics, data site and BMI percentile
- Weighted on demographics, data site and BMI percentile
Main finding
Incident diabetes
Cumulative incidence ratio (CIR)
1.03
95% CI 0.65–1.41
As reported in the abstract
Observational data: associations, not effects.
Further findings
Diabetes subtype
- Predominant subtype of incident diabetes was T2D
Incidence rates over time
- U-shaped curve, highest incidence in ancestral variant period
Original publication
The Effect of COVID‐19 on Incident Diabetes in Pediatric Patients: Findings From the National COVID‐19 Cohort Collaborative (N3C). Pediatr Diabetes. Published 5 December 2025. doi:10.
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