Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus
Authors' conclusion
These results suggest that activated cellular kinases (i.e., PKC, AMPK, MAPK, and SYK) and multiple EV-shuttled kinases (i.e., PKCβ, BTK, TEC, MAP2K2, and ROCK1) may play key roles in severe COVID-19, particularly in patients with comorbid diabetes.
Study context
- Population
- Patients with and without T2D hospitalized with COVID-19 or non-COVID-19 acute respiratory illness
- Comparison
- Patients with vs without T2D hospitalized with COVID-19 or non-COVID-19 acute respiratory illness (RSP)
- Outcome
- Circulating EV proteomic and phosphoproteomic landscape
Main finding
As reported in the abstract
- Differentially expressed protein and phosphoprotein signatures effectively characterized the study groups
- C1QA, C1QB and C1QC appeared to be a central cluster in both the COVID-19 and T2D functional networks
- PKCβ appeared to be retained in cells, diverted from EV pathways, and to contribute to the COVID-19–T2D interaction via a PKC/BTK/TEC axis
- EV-shuttled CASP3 and ROCK1 appeared coregulated and likely contribute to disease interactions in COVID-19 with T2D
- Predicted activation of AMPK, MAPK and SYK appeared to play important roles driving disease interaction
Original publication
Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 1 February 2023. doi:10.
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