The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors
An erratum to this article was published (Cardiovasc Diabetol, 29 May 2023 ↗)
Authors' conclusion
In NFAT patients, F-1mgDST 1.2-1.79 µg/dL seems to be associated with a higher prevalence of HT and DM and a worse cardiometabolic profile, even if the poor accuracy of these associations suggests caution in interpreting these results.
Study context
- Population
- Patients with nonfunctioning adrenal tumors (F-1mgDST <1.8 µg/dL [50 nmol/L])
- Participants
- 615 patients
- Exposure
- F-1mgDST 1.2-1.79 µg/dL vs F-1mgDST <1.2 µg/dL
- F-1mgDST 1.2-1.79 µg/dLn = 326
- F-1mgDST < 1.2 µg/dLn = 289reference
- Outcome
- Prevalence of HT, DM, HT plus DM and CVE
Main finding
As reported in the abstract
F-1mgDST 1.2-1.79 µg/dL vs F-1mgDST < 1.2 µg/dLEstimate (95% CI)P value
Adjusted for age, gender, OB, DL, DM
OR (HT) 1.55(1.08–2.23)
P = 0.018Adjusted for age, gender, OB, DL, HT
OR (DM) 1.60(1.01–2.57)
P = 0.045Adjusted for age, gender, OB, DL
OR (HT plus DM) 1.96(1.12–3.41)
P = 0.018- Hypertension (HT) prevalence, P
- P < 0.001
- Diabetes mellitus (DM) prevalence, P
- P = 0.001
- HT plus DM prevalence, P
- P < 0.002
- Cardiovascular events (CVE) prevalence, P
- P = 0.028
Observational data: associations, not effects.
Further findings
ACTH
P = 0.008
Age
P < 0.001
Association of F-1mgDST with HT, DM, HT plus DM (AUC)
- AUC HT
- 0.588 ± 0.023
- AUC DM
- 0.610 ± 0.028
- AUC HT plus DM
- 0.611 ± 0.033
- P for all
- P < 0.001
- Cut-off for HT, DM or HT plus DM
- ≥ 1.2 µg/dL (33 nmol/L)
- No association with adrenocorticotroph hormone (ACTH)
Original publication
The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors. Cardiovasc Diabetol. Published 2 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →