The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery
Authors' conclusion
The higher early-life weight gain and sex differences in the post-MBS-sleeve group compared with the post-MBS-bypass group provide a window toward elucidating pathways to mitigate intergenerational metabolic risk transfer.
Study context
- Population
- Single-center deliveries, January 2020–March 2023; 76% Hispanic/Latino in metabolic and bariatric surgery (MBS) group440 with prepregnancy MBS
- Participants
- 185 / 225 / 13,434
- Exposure
- Prepregnancy MBS vs non-MBS controls
- MBS-bypassn = 185
- MBS-sleeven = 225
- Non-MBS controlsn = 13,434reference
- Outcome
- Offspring weight gain
- Follow-up
- 24 months
Methodological detailssingle-center, propensity score-matched controls
- Single-center
- Propensity score-matched controls
Main finding
As reported in the abstract
Weight gain difference
+1.4 kg
95% CI 1.0–1.9
MBS-sleeve
Weight gain difference
+0.5-0.7 kg
95% CI 0.0–1.2
MBS-bypass
Observational data: associations, not effects.
Further findings
Maternal gestational outcomes
- Gestational weight gain and GDM similar; hypertensive disorders of pregnancy more common after MBS
Offspring weight gain by sex
- Male children had higher weight gain than females
Offspring BMI z scores
- Higher BMI z scores in post-MBS-sleeve but not post-MBS-bypass offspring
Original publication
The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery. Obesity (Silver Spring). Published 5 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →