The Association Between Plasma Fatty Acids and Risk of Lung Cancer: A Prospective Cohort Study of the UK Biobank
Authors' conclusion
Our findings suggest that plasma PUFAs may serve as protective factors, while MUFAs represent risk factors for lung cancer, offering novel insights into lung cancer carcinogenesis and prevention.
Study context
- Population
- Cancer-free participants from the UK Biobank with plasma fatty acids (FAs) (saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs)) measured at baseline (2006–2010)1,122 lung cancer cases
- Participants
- 112,547 participants
- Exposure
- Plasma FA levels and lung cancer risk
- Outcome
- Lung cancer incidence
- Follow-up
- average 10.9-year follow-up
Methodological detailsUK Biobank, multivariable-adjusted Cox regression, additive interaction with polygenic risk score
- UK Biobank
- Multivariable-adjusted Cox regression
- Additive interaction with polygenic risk score
Main finding
As reported in the abstract
Lung cancer risk by plasma FAs
MUFAs, HR per 1-SD
1.32 (1.13-1.54) (95% CI)
PUFAs (particularly n-3 PUFAs, n-6 PUFAs, docosahexaenoic acid, linoleic acid) associated with lower risk; HRs ranging from
0.79 (95% CI, 0.72-0.87) to 0.89 (95% CI, 0.83-0.95)
Observational data: associations, not effects.
Further findings
- High genetic risk and lowest quartile of plasma PUFAs had the highest risk, HR
- 2.20 (1.43-3.38) (95% CI)
- Additive interaction between plasma PUFAs and genetic risk observed
Original publication
The Association Between Plasma Fatty Acids and Risk of Lung Cancer: A Prospective Cohort Study of the UK Biobank. J Clin Endocrinol Metab. Published 3 September 2024. doi:10.
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