Debulking Surgery After Muscular Paraffin Oil Injections: Effects on Calcium Homeostasis and Patient Satisfaction
Authors' conclusion
Surgery improved calcium homeostasis in a fraction of patients and reduced inflammation and subjective symptoms such as pain and mental well-being in a patient group left with few treatment options except high-dose prednisolone.
Study context
- Population
- Patients undergoing debulking surgery after cosmetic muscular paraffin oil injections; age 34.6 years (SD 6.9)
- Participants
- 33 patients
- Exposure
- Hypercalcemia vs Normocalcemic
- Hypercalcemian = 17
- Normocalcemicn = 16
- Outcome
- Changes in calcium, inflammatory markers and renal function
- Follow-up
- Baseline up to 12 months after surgery
Main finding
As reported in the abstract
Ionized calcium at baseline (Hypercalcemia)
1.48 mmol/L
SD 0.16
Ionized calcium at 12 months (Hypercalcemia)
1.33 mmol/L
SD 0.03P < .002
Became normocalcemic (Hypercalcemia)
4 men
23.5%
Observational data: associations, not effects.
Further findings
Serum ferritin, hypercalcemic patients · up to 12 months
- Ferritin reduced by 50%
- P = 0.048
Serum ferritin, normocalcemic patients · after surgery
- Ferritin dropped 20%
- P = 0.025
Patients completing all planned surgeries (n=15)
- Decline in serum ionized calcium
- P = 0.031
- Decline in ferritin
- P = 0.011
- Decline in interleukin 2-receptor
- P = 0.037
Patient survey · after surgery
- Postoperative satisfaction score 10/10
- 55%
- Reduced pain
- 59%
Original publication
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