The association between PFAS exposure, menstrual cycle parameters, and reproductive hormones in adolescent girls
Authors' conclusion
PFAS were widely detected in healthy girls. PFBS was positively associated with E1G levels, suggesting potential ovarian effects.
Study context
- Population
- Adolescent girls, 12.8 ± 1.0 years old (mean ± SD), gynecologic age 0.3 ± 0.2 years; most non-Hispanic White and of normal weight88 serum samples
- Participants
- 38 participants
- Outcome
- Associations between PFAS and total cycle, follicular phase and luteal phase lengths and urinary creatinine (Cr)-corrected LH, E1G and PdG levels
Methodological detailslinear mixed-effects models, unadjusted and adjusted for gynecologic age, body fat percent and race/ethnicity
- Linear mixed-effects models
- Unadjusted and adjusted for gynecologic age, body fat percent and race/ethnicity
Main finding
As reported in the abstract
PFBS positively associated with peak E1G levels: β (95% CI), P
β = .15, 95% CI
0.00, 0.29P = .049
Observational data: associations, not effects.
Original publication
The association between PFAS exposure, menstrual cycle parameters, and reproductive hormones in adolescent girls. J Clin Endocrinol Metab. Published 1 April 2026. doi:10.
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