The association between interleukin family and diabetes mellitus and its complications: An overview of systematic reviews and meta-analyses
Authors' conclusion
Multiple ILs, such as the IL-6 and IL-1β, are definitively linked to DM and its complications, and they may be new targets for the diagnosis and treatment, but stronger evidence needs to be confirmed by prospective studies with larger sample sizes and longer observation periods.
Study context
- Population
- Meta-analyses and eligible individual observational studies of the association between interleukin (IL) and diabetes mellitus (DM) and its complications34 meta-analyses
- Comparison
- Interleukin concentrations and DM and its complications
- Outcome
- Association of IL concentrations with DM and its complications
Methodological detailsumbrella review, random-effects model, heterogeneity assessed by Q-statistic and I2, Egger's regression and χ2 test for small study effects and excess significance bias
- Umbrella review
- Random-effects model
- Heterogeneity assessed by Q-statistic and I2
- Egger's regression and χ2 test for small study effects and excess significance bias
Pooled result
As reported in the abstract
Incident T2D per 1 log pg/ml increment in IL-6 (meta-analyses of prospective studies), HR
1.28
95% CI 1.17, 1.40; P＜0.001
Original publication
The association between interleukin family and diabetes mellitus and its complications: An overview of systematic reviews and meta-analyses. Diabetes Res Clin Pract. Published 19 March 2024. doi:10.
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