Major adverse events in youth-onset type 1 and type 2 diabetes: The SEARCH and TODAY studies
Authors' conclusion
In youth-onset diabetes, end-organ events were infrequent but did occur before 15 years diabetes duration. Rates were higher and had different risk factors in T2D versus T1D.
Study context
- Population
- Youth-onset T1D and T2D; SEARCH (in-person interviews 2018–2019) and TODAY (semi-annual interviews 2014–2020)
- Exposure
- Youth-onset T2D vs T1D
- T1Dn = 564reference
- Outcome
- Incidence rates and risk factors for major adverse events
Methodological detailsharmonized, predetermined, standardized adjudication criteria
- Harmonized, predetermined, standardized adjudication criteria
Main finding
As reported in the abstract
Incidence rates of major adverse events (events per 10,000 person-years)
Fold higher, microvascular
2.5
T2D
Fold higher, macrovascular
4.0
T2D
Fold higher, gastrointestinal disease
2.7
T2D
Observational data: associations, not effects.
Further findings
Risk factors (univariate logistic regression)
- T1D: age at diagnosis, female sex, HbA1c and mean arterial pressure (MAP) associated with microvascular events
- T2D: composite microvascular events associated positively with MAP and negatively with BMI
- T2D: composite macrovascular events associated solely with MAP
Original publication
Major adverse events in youth-onset type 1 and type 2 diabetes: The SEARCH and TODAY studies. Diabetes Res Clin Pract. Published 15 March 2024. doi:10.
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