Gestational diabetes & diabetes in pregnancy
The association between adverse childhood experiences (ACEs) and gestational diabetes mellitus (GDM): A systematic review and meta-analysis
Authors' conclusion
Overall, ACEs are associated with increased risk of GDM, supporting a life-course approach to maternity care.
Study context
- Population
- Observational studies of ACEs before age 18 and GDM; 9 databases searched to 30 May 202511 studies in meta-analysis
- Participants
- 326,797 participants
- Comparison
- ACE exposure before age 18 vs no ACE exposure
- Outcome
- GDM
Methodological detailsrandom-effects models, dose-response analysis (Greenland-Longnecker method), ROBINS-E risk of bias, Two reviewers independently screened, extracted data and assessed risk of bias
- Random-effects models
- Dose-response analysis (Greenland-Longnecker method)
- ROBINS-E risk of bias
- Two reviewers independently screened, extracted data and assessed risk of bias
Pooled result
As reported in the abstract
Adjusted odds ratio (95% CI)
ACE exposureI2 = 0%
1.15(1.12–1.18)
Each additional ACEcumulative dose-response
1.13(1.08–1.19)
Each additional ACE, as printed
Original publication
The association between adverse childhood experiences (ACEs) and gestational diabetes mellitus (GDM): A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 19 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →