The acute effects of a DASH diet and whole food, plant-based diet on insulin requirements and related cardiometabolic markers in individuals with insulin-treated type 2 diabetes
Authors' conclusion
Adopting a DASH or WFPB diet can result in significant, rapid changes in insulin requirements, insulin sensitivity, and related markers among individuals with insulin-treated type 2 diabetes, with larger dietary changes producing larger benefits.
Study context
- Population
- Individuals with insulin-treated T2D
- Participants
- 15 individuals
- Comparison
- DASH and WFPB diets vs baseline
- Outcome
- Acute changes in insulin requirements
Methodological detailssequential one-week phases, ad libitum, meals provided, 4-week trial with sequential one-week phases: Baseline, DASH 1, WFPB, DASH 2
- Sequential one-week phases
- Ad libitum
- Meals provided
- 4-week trial with sequential one-week phases: Baseline, DASH 1, WFPB, DASH 2
Main finding
As reported in the abstract
% lower
24%
P < 0.01
DASH 1 vs Baseline · lower with DASH 1
% lower
39%
P < 0.01
WFPB vs Baseline · lower with WFPB
% lower
30%
P < 0.01
DASH 2 vs Baseline · lower with DASH 2
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Insulin resistance (HOMA-IR) · end of WFPB weekWFPB vs Baseline · lower with WFPB | % lower 49% | P < 0.01 |
| Insulin sensitivity index · end of WFPB weekWFPB vs Baseline · higher with WFPB | % higher 38% | P < 0.01 |
Insulin resistance (HOMA-IR) · end of WFPB week
- Regressed toward baseline during DASH 2
Insulin sensitivity index · end of WFPB week
- Regressed toward baseline during DASH 2
Total, LDL and HDL cholesterol, leptin, urinary glucose, hsCRP
- Decreased to a nadir at end of WFPB week before increasing during DASH 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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