Balanced diets are associated with a lower risk of type 2 diabetes than plant-based diets
Authors' conclusion
Adhered to a balanced diet is associated with a lower risk of diabetes compared to plant-based diet, which might be attributed to signature proteins such as AGR2, DBI, IL17RA and SERPINH1.
Study context
- Population
- Participants of the Environment-Inflammation-Metabolic-Diseases Study (EIMDS) and UK Biobank
- Exposure
- Balanced diets vs plant-based diets
- Outcome
- Diabetes risk
Methodological detailscross-sectional analysis (EIMDS), prospective analysis (UK Biobank), proteomic analysis, summary-data-based Mendelian randomization (SMR)
- Cross-sectional analysis (EIMDS)
- Prospective analysis (UK Biobank)
- Proteomic analysis
- Summary-data-based Mendelian randomization (SMR)
Main finding
As reported in the abstract
Diabetes
Balanced diets vs Plant-based dietsEstimate (95% CI)
EIMDS, cross-sectional
OR 0.65(0.44–0.95)
UK Biobank, excluding unhealthy plant-based diets
HR 0.86(0.77–0.95)
Observational data: associations, not effects.
Further findings
Proteomic signature proteins of balanced diets
- Downregulated proteins associated with higher diabetes risk
- 107
- Upregulated proteins associated with lower diabetes risk
- 2
- In SMR, downregulated signature proteins (AGR2, DBI, IL17RA, SERPINH1) causally associated with diabetes incidence
Original publication
Balanced diets are associated with a lower risk of type 2 diabetes than plant-based diets. Diabetes Res Clin Pract. Published 28 December 2024. doi:10.
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