Temporal Trends in Distal Symmetric Polyneuropathy in Type 2 Diabetes: The Fremantle Diabetes Study
Main finding · DSPN prevalence by 6-point MNSI (excluding foot appearance)Result — go to the resultOdds ratio 0.68 95% CI 0.56–0.83Authors' conclusion
DSPN prevalence was lower or equivalent in FDS2 vs FDS1, and its incidence was greater or lower, in multivariable models depending on the MNSI features used.
Study context
- Population
- Community-based Australians with T2D, urban population
- Participants
- 1,296 vs 1,509
- Exposure
- Fremantle Diabetes Study phase II vs phase I
- FDS1n = 1,296reference
- FDS2n = 1,509
- Outcome
- Michigan Neuropathy Screening Instrument (MNSI) clinical grading
Methodological detailscommunity-based, urban population, two-phase comparison
- Community-based
- Urban population
- Two-phase comparison
Main finding
As reported in the abstract
DSPN prevalence by 6-point MNSI (excluding foot appearance)
Odds ratio
0.68
95% CI 0.56–0.83
P < 0.001
By group
FDS2vs FDS1
OR 0.68 (95% CI 0.56–0.83); P < 0.001
Observational data: associations, not effects.
Further findings
DSPN prevalence by 8-point MNSI
P < 0.001
DSPN prevalence by 2-point MNSI (biothesiometry alone) · unadjusted
P = 0.011
| Outcome | FDS1 | FDS2 | Estimate | P value | |
|---|---|---|---|---|---|
| DSPN prevalence by 2-point MNSI (biothesiometry alone)Multivariable analysis | OR 0.90 (95% CI 0.74–1.11) | P = 0.326 | |||
| DSPN incidence rate by 6-point MNSI · 4 years | 13.6 (95% CI 12.0–15.4) /100 person-years | 17.6 (95% CI 15.9–19.4) /100 person-years | IRR 1.31 (95% CI 1.12–1.55) | P < 0.001 | |
| DSPN incidence rate by 6-point MNSI · 4 yearsIndependent predictor of incident DSPN | HR 1.25 (95% CI 1.06–1.48) | P = 0.009 | |||
| DSPN incidence rate by 2-point MNSI · 4 years | 13.9 (95% CI 12.3–15.8) /100 person-years | 7.4 (95% CI 16.3–8.6) /100 person-years | IRR 0.53 (95% CI 0.43–0.64) | P < 0.001 | |
| DSPN incidence rate by 2-point MNSI · 4 yearsIndependent predictor of incident DSPN | HR 0.42 (95% CI 0.33–0.55) | P < 0.001 | |||
| 0.20.5125Ratio (log scale) |
- Distal symmetric polyneuropathy (DSPN) prevalence by 8-point Michigan Neuropathy Screening Instrument (MNSI): Not analysed further given between-phase changes in appearance assessment
- DSPN incidence rate by 2-point MNSI: FDS2 CI as printed
Original publication
Temporal Trends in Distal Symmetric Polyneuropathy in Type 2 Diabetes: The Fremantle Diabetes Study. J Clin Endocrinol Metab. Published 1 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →