Circulating metabolomic markers in association with overall burden of microvascular complications in type 1 diabetes
Authors' conclusion
While prospective studies directly assessing the predictive ability of these markers are needed, our results strengthen the role of clinical metabolomics in relation to risk assessment of diabetic complications in chronic type 1 diabetes.
Study context
- Population
- Adults with T1D; 49 metabolites previously associated with diabetic retinopathy (DR) or diabetic kidney disease (DKD) assessed in relation to distal symmetric polyneuropathy (DSPN), microvascular burden severity and progression to microvascular/macrovascular events202 in cross-sectional cohort
- Participants
- 487 adults
- Outcome
- Metabolites associated with presence of DR, DKD and DSPN, and with additive microvascular burden severity
Methodological detailscross-sectional and longitudinal analyses, adjusted Cox and linear regression models
- Cross-sectional and longitudinal analyses
- Adjusted Cox and linear regression models
Main finding
As reported in the abstract
Metabolites significantly associated with presence of DR, DKD and DSPN
8
Metabolites significantly associated with additive microvascular burden severity
6
Observational data: associations, not effects.
Original publication
Circulating metabolomic markers in association with overall burden of microvascular complications in type 1 diabetes. BMJ Open Diabetes Res Care. Published 11 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →