Temporal Trends and Disparities in Cardiovascular Mortality Among Adults With Obesity in the United States From 1999 to 2023
Authors' conclusion
Cardiovascular mortality among US adults with obesity tripled over 25 years, with widening disparities across demographic and geographic groups, necessitating equitable public health interventions targeting high-risk populations.
Study context
- Population
- Adults aged ≥25 years in the United States (1999–2023) with CVD as underlying cause of death and obesity as contributing cause
- Participants
- 363,203 CVD deaths
- Outcome
- Age-adjusted mortality rates (AAMR) per 100,000 population
- Follow-up
- 1999-2023
Methodological detailsCDC WONDER Multiple Cause of Death data, joinpoint regression analysis
- CDC WONDER Multiple Cause of Death data
- Joinpoint regression analysis
Main finding
As reported in the abstract
AAMR (CVD mortality with obesity) · 1999 to 2023
Age-adjusted mortality rates (AAMR) tripled (per 100,000)
3.40 to 10.34
Average annual percent change (AAPC)
+4.88%
Pandemic acceleration (2018-2021), annual increase
12.22%
Observational data: associations, not effects.
Further findings
AAMR by sex · 2023 · Men had higher mortality than women
AAMR trend by age
- 75-84 years showed the steepest increase, AAPC
- +5.66%
AAMR by race/ethnicity · 2023
- Non-Hispanic Black adults had the highest AAMR (per 100,000)
- 18.30
AAMR by region
- South went from lowest to highest regional burden, AAPC
- +5.52%
Disease spectrum
- Shift toward atherosclerotic and hypertensive conditions
Original publication
Temporal Trends and Disparities in Cardiovascular Mortality Among Adults With Obesity in the United States From 1999 to 2023. Obesity (Silver Spring). Published 11 February 2026. doi:10.
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