Surgical management in very elderly patients with pituitary adenoma: a multivariable assessment of the surveillance, epidemiology, and end results database
Authors' conclusion
In patients ≥ 85 years of age with pituitary adenoma, surgical resection appears to provide an overall benefit to survival and should be considered among other factors.
Study context
- Population
- Patients with pituitary adenoma aged ≥85 years, with a 75–84-year cohort for comparison, SEER database
- Exposure
- Factors associated with survival, incl. surgical resection, in very elderly (≥85 years) vs elderly (75-84) cohorts
- Outcome
- Overall survival
Methodological detailsSEER database, multivariable Cox proportional hazards models stratified by age cohort
- SEER database
- Multivariable Cox proportional hazards models stratified by age cohort
Main finding
As reported in the abstract
Factors associated with overall survival, very elderly cohort
Adenoma size, worse overall survival: HR
1.004
p = 0.005
Female sex, increased overall survival: HR
0.656
p < 0.001
Subtotal resection, increased overall survival: HR
0.557
p = 0.005
Observational data: associations, not effects.
Further findings
Factors associated with survival, all cohorts
- Subtotal resection and female sex independently associated with improved survival; age associated with worse survival
Black race and survival, elderly (75-84) cohort
- Black race associated with worse survival in 75-84 cohort only: HR
- 1.479; p < 0.001
Original publication
Surgical management in very elderly patients with pituitary adenoma: a multivariable assessment of the surveillance, epidemiology, and end results database. Pituitary. Published 20 December 2025. doi:10.
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