Subsequent primary malignancies in patients with initial diagnosis of pituitary adenoma: a surveillance, epidemiology, and end results (SEER) data analysis
Main finding · SPM after pituitary adenoma diagnosisResult — go to the resultStandardized incidence ratio 1.1 99% CI 1.06–1.15Authors' conclusion
Utilizing the SEER database, we have discovered an increased risk of SPM in patients with pituitary adenoma. Supplementary research may be done to determine any shared genetic abnormalities between the development of pituitary adenoma and these SPMs. Additionally, further research of the endocrinological effects of pituitary adenoma and potential associations to SPMs should be studied.
Study context
- Population
- Patients diagnosed with pituitary adenoma in the Surveillance, Epidemiology, and End Results (SEER-17) registry, 2000–2020
- Participants
- 60,677 patients
- Exposure
- Patients with pituitary adenoma vs general population
- Pituitary adenoman = 60,677
- Outcome
- Risk of subsequent primary malignancy (SPM) after pituitary adenoma diagnosis (SIR)
Methodological detailspopulation-based registry analysis, SEER-17
- Population-based registry analysis
- SEER-17
Main finding
SPM after pituitary adenoma diagnosis
Standardized incidence ratio
1.1
99% CI 1.06–1.15
Pituitary adenoma cohortvs General population
SIR 1.1 (99% CI 1.06–1.15)
As reported in the abstract
- Received a diagnosis of a subsequent primary malignancy (SPM), of 60,677 patients
- 4067 (6.7%)
Observational data: associations, not effects.
Further findings
| Outcome | SIR (99% CI) | |
|---|---|---|
| Lymphatic and hematopoietic cancer | 1.25 (1.09–1.41) | |
| Kidney and renal pelvis cancer | 1.45 (1.2–1.74) | |
| Thyroid cancer | 2.76 (2.32–3.26) | |
| 0.20.5125Standardized incidence ratio (log scale) |
| Outcome | SIR (99% CI) |
|---|---|
| Cutaneous melanomaEstimate outside its printed CI | 1.36 (1.15–1.16) |
Digestive system cancer, females
- Females more predisposed to digestive system cancer: SIR
- 1.19 (1.11-1.25) (99% CI)
Non-Hodgkin's lymphoma, females
- Females more predisposed to non-Hodgkin's lymphoma: SIR
- 1.41 (1.04-1.88) (99% CI)
Original publication
Subsequent primary malignancies in patients with initial diagnosis of pituitary adenoma: a surveillance, epidemiology, and end results (SEER) data analysis. Pituitary. Published 9 February 2026. doi:10.
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