Successful treatment of medically and surgically refractory lymphocytic hypophysitis with fractionated stereotactic radiotherapy: a single-center experience and systematic literature review
Authors' conclusion
Focused radiation, including FSRT, can play a role in symptomatic relief, effective mass shrinkage, and minimizing radiation exposure to critical surrounding structures in patients with refractory LH. However, further research efforts are necessary to better clarify its effects and optimal dose planning.
Study context
- Population
- Patients with lymphocytic hypophysitis (LH) refractory to medical therapy and surgery; age 37 to 75 years, median 58; 3 from authors' institution and 5 from existing literature3 institutional, 5 literature
- Participants
- 8 patients
- Exposure
- Stereotactic radiosurgery (SRS) vs FSRT
- SRSn = 3
- Outcome
- Response after focused radiotherapy
Methodological detailssingle-center, PRISMA guidelines, Mean irradiation volume 2.2 cm³
- Single-center
- PRISMA guidelines
- Mean irradiation volume 2.2 cm³
Main finding
As reported in the abstract
- Resolution of visual field defects
- 4 patients
- Improvement in associated focal neurologic deficits
- 2 patients
- Clinical response after a single course of radiation
- 7 patients
- Required a second course
- 1 patient
- Complete radiologic response
- 3 patients
- Partial radiologic response
- remaining patients
Observational data: associations, not effects.
Further findings
Endocrine status and glucocorticoid use · at least 12-month follow-up
- No change in pre-existing endocrine status after radiation, except in
- 1 patient
- Stable on low-dose glucocorticoid
- 6 patients
- Discontinued glucocorticoid entirely without relapse
- 1 patient
Original publication
Successful treatment of medically and surgically refractory lymphocytic hypophysitis with fractionated stereotactic radiotherapy: a single-center experience and systematic literature review. Pituitary. Published 25 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →