Subtypes of pre-diabetes in rural adolescent girls from India (DERVAN-11)
Authors' conclusion
We demonstrated the existence of a distinct lean pre-diabetic phenotype in adolescent girls whose characteristics seem to mirror those of adult type 5 diabetes, which has been recently recognized as a distinct entity.
Study context
- Population
- Rural adolescent girls with pre-diabetes (ADA criteria), DERVAN cohort, predominantly undernourished KONKAN region of India550 pre-diabetic
- Participants
- 1,382 participants
- Exposure
- Young lean (YL) vs old lean (OL) vs Low body mass index (BMI)-high waist vs Normal BMI-low waist vs Obese
- YLn = 145
- OLn = 131
- Low BMI-high waistn = 146
- Normal BMI-low waistn = 74
- Obesen = 54
- Outcome
- Pre-diabetes clusters by BMI, waist circumference and adiposity
Methodological detailsunsupervised K-means clustering, subgrouping algorithm
- Unsupervised K-means clustering
- Subgrouping algorithm
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prevalence of thinness and pre-diabetes
- Thin
- 809 (58.5%)
- Pre-diabetic
- 550 (39.8%)
Subgroup analysis: lean pre-diabetic phenotype
- Distinct lean pre-diabetic phenotype with lowest BMI (<18.5 kg/m²), no central obesity or adiposity, and lowest fasting insulin, HOMA-IR and homeostatic model assessment (HOMA)-β vs remaining subgroups
- n=314
Original publication
Subtypes of pre-diabetes in rural adolescent girls from India (DERVAN-11). BMJ Open Diabetes Res Care. Published 8 September 2026. doi:10.
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