Lean diabetes is one end of the spectrum of type 2 diabetes and not a separate entity
Authors' conclusion
Lean diabetes is one end of the spectrum of T2D and is characterized by an earlier age of onset, more severe insulin deficiency and increased risk of microvascular complications.
Study context
- Population
- Individuals with T2D at a tertiary care diabetes centre in South India
- Participants
- 398,258 individuals
- Exposure
- Lean T2D vs normal weight, overweight, mildly obese and markedly obese T2D
- Leann = 5,865
- Outcome
- Prevalence, clinical and microvascular complication profile of lean diabetes
Methodological detailssingle-centre, electronic records
- Single-centre
- Electronic records
Main finding
As reported in the abstract
Prevalence of lean diabetes
Lean
1.5 %
5865
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Microvascular complicationsLean vs Other groups | P < 0.001 | |
| Insulin treatmentLean vs Other groups · more likely with Lean | Lean 55.6 % | P < 0.001 |
- Microvascular complications — Retinopathy in lean T2D
- 42%
- Microvascular complications — Nephropathy in lean T2D
- 39 %
- Microvascular complications — Neuropathy in lean T2D
- 73 %
- Microvascular complications: higher prevalence of retinopathy, nephropathy and neuropathy with Lean
Clinical and biochemical features
- Lean T2D were younger with male preponderance, had higher fasting and postprandial plasma glucose and HbA1c, lower C-peptide and serum cholesterol vs normal weight, overweight and obese T2D
Original publication
Lean diabetes is one end of the spectrum of type 2 diabetes and not a separate entity. Diabetes Res Clin Pract. Published 25 July 2025. doi:10.
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