Strong independent association between third-degree AV-block and diabetes mellitus using a large database
Authors' conclusion
DM is independently associated with third-degree AV-block with persistent association over a period of 10 years. The cause of this association warrants further investigation.
Study context
- Population
- Inpatients in the Nationwide Inpatient Sample (NIS) database, 1992 and 2002, identified by ICD-9 codestwo NIS databases
- Exposure
- Third-degree AV-block vs control
- Outcome
- Independent association between DM and third-degree AV-block
Methodological detailsNationwide Inpatient Sample database, two independent samples (1992 and 2002), uni- and multivariate analysis
- Nationwide Inpatient Sample database
- Two independent samples (1992 and 2002)
- Uni- and multivariate analysis
Main finding
As reported in the abstract
Independent association of DM with third-degree AV block (multivariate, adjusted for age, congestive heart failure and coronary artery disease)
Adjusted OR, database labelled "1999" (as printed)
OR 2.54, CI 2.51-2.57
p < 0.0001
Adjusted OR, 2002 database
OR 1.56, CI 1.55-1.57
p < 0.0001
Observational data: associations, not effects.
Further findings
%
| Outcome | Third-degree AV-block | Control | OR (CI) | P value | |
|---|---|---|---|---|---|
| DM, univariate, 1992 database | 0.5 | 0.2 | 2.15 (2.06–2.25) | P < 0.0001 | |
| DM, univariate, 2002 database | 0.4 | 0.2 | 1.86 (1.80–1.93) | P < 0.0001 | |
| 0.512Odds ratio (log scale) |
- DM, univariate, 1992 database: 1992 database: 6,195,744 patients
- DM, univariate, 2002 database: 2002 database: 7,853,982 patients
Original publication
Strong independent association between third-degree AV-block and diabetes mellitus using a large database. Diabetes Res Clin Pract. Published 12 October 2023. doi:10.
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