Endometriosis subtypes and risk of type 2 diabetes: the Advancing Research on Cardiovascular Health and Endometriosis Study (ARCHES) retrospective cohort study
An erratum to this article was published (Diabetologia, Dec 2026 ↗)
Main finding · Incident T2DResult — go to the resultAdjusted hazard ratio 1.46 95% CI 1.43–1.50Authors' conclusion
Endometriosis was associated with increased type 2 diabetes risk, with substantial heterogeneity by subtype and metabolic context. Associations were strongest among individuals who are traditionally considered at lower baseline risk, although these findings should be interpreted cautiously given the potential for residual confounding and detection bias.
Study context
- Population
- Individuals assigned female at birth, Utah Population Database (1996–2021)population-based cohort
- Participants
- 2,939,364 individuals
- Exposure
- Endometriosis vs no endometriosis
- Endometriosisn = 99,978
- Outcome
- Incident T2D (ICD codes)
- Follow-up
- Mean 10.8 years
Methodological detailspopulation-based, dynamic cohort, time-varying exposures
- Population-based
- Dynamic cohort
- Time-varying exposures
Main finding
Incident T2D
Adjusted hazard ratio
1.46
95% CI 1.43–1.50
Endometriosisvs No endometriosis
aHR 1.46 (95% CI 1.43–1.50)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| T2D by subtype: 'other site' endometriosisSpecified sitevs No endometriosis | 2.67 (2.51–2.84) | |
| T2D by subtype: 'other site' endometriosisUnspecified sitevs No endometriosis | 2.47 (2.35–2.60) | |
| T2D, premenopausal womenStronger than in postmenopausal women | 1.55 (1.50–1.60) | |
| T2D, BMI <30 kg/m²Stronger than in higher BMI categories | 2.39 (2.34–2.44) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
T2D by subtype: 'other site' endometriosis
- Risk varied by subtype; strongest associations for 'other site' endometriosis
T2D by history of GDM
- Associations present regardless of history of GDM
Original publication
Endometriosis subtypes and risk of type 2 diabetes: the Advancing Research on Cardiovascular Health and Endometriosis Study (ARCHES) retrospective cohort study. Diabetologia. Published 6 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →