Strength of Genetic Associations with Thyrotropin Values Differs Between Populations with Similarity to African and European Reference Populations
Authors' conclusion
Patterns of genetic associations with TSH differed between identically sized GSA and GSE groups. Failure to replicate the strongest associations previously reported in GSE individuals in our GSA population was not fully explained by differences in allele frequencies or power, assuming similar effect sizes.
Study context
- Population
- Individuals with TSH values between 0.45 and 4.5 mU/L
- Participants
- 9,827 vs 9,827
- Comparison
- GSA vs GSE groups: genome-wide associations with TSH and putative causal TSH-associated variants
- GSAn = 9,827
- GSEn = 9,827reference
- Outcome
- Genome-wide associations with TSH
Methodological detailscomparison of identically sized ancestry-similarity groups
- Comparison of identically sized ancestry-similarity groups
Main finding
As reported in the abstract
Loci attaining genome-wide significance, GSA
4
Loci attaining genome-wide significance, GSE
7
Putative causal variants with significantly different effect sizes between groups
8
Further findings
Power to detect associations with putative causal variants
- Power in GSA to detect associations with variants in PDE8B, PDE10A, NFIA and LOC105377480
- ≥80%
- Higher expected power in GSA than GSE for variants in PDE8B, NFIA and LOC105377480; similar power for other variants in PDE8B and PDE10A
Additional putative causal variants in PDE8B and PDE10A
- No additional variants had effect sizes differing significantly between groups; power similar between groups
Original publication
Strength of Genetic Associations with Thyrotropin Values Differs Between Populations with Similarity to African and European Reference Populations. Thyroid. Published 27 January 2025. doi:10.
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