Statistically Adjusting for Wear Time in Randomized Trials of Continuous Glucose Monitors as a Complement to Intent-to-Treat and As-Treated Analyses: Application and Evaluation in Two Trials
Authors' conclusion
In trials of CGM use, the effect of variable wear time is non-negligible.
Study context
- Population
- Participants of two 6-month continuous glucose monitoring (CGM) trials spanning diverse ages (Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) and CITY)2 trials
- Comparison
- Instrumental variable (IV)-based vs ITT estimates of CGM effect
Methodological detailsmethodological study, instrumental variable approach, treatment assignment as instrument
- Methodological study
- Instrumental variable approach
- Treatment assignment as instrument
Primary result
As reported in the abstract
CGM wear time · 28-day window and full trial period
| Group | Value | Full trial period |
|---|---|---|
| WISDM | 93.1% (SD 20.4) | 94.5% (SD: 11.9) |
| CITY | 82.2% (SD 26.5) | 83.1% (SD: 21.5) |
Value
WISDM93.1% (SD 20.4)
CITY82.2% (SD 26.5)
Full trial period
WISDM94.5% (SD: 11.9)
CITY83.1% (SD: 21.5)
Original publication
Statistically Adjusting for Wear Time in Randomized Trials of Continuous Glucose Monitors as a Complement to Intent-to-Treat and As-Treated Analyses: Application and Evaluation in Two Trials. Diabetes Technol Ther. Published 25 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →