Differences Between Glycemia Estimates from Hemoglobin A1c and Continuous Glucose Monitoring and Their Association with Complete Blood Counts
An erratum to this article was published (Diabetes Technol Ther, May 2026 ↗)
Authors' conclusion
CBC measurements are associated with differences between estimates of glycemia derived from HbA1c and CGM. Further studies with longer periods of CGM are needed to determine whether CBCs can complement HbA1c and CGM and can help reconcile differences in estimates of mean glycemia provided by HbA1c and CGM.
Study context
- Population
- Individuals with T2D in the GRADE CGM substudy
- Participants
- 1,325 individuals
- Comparison
- Complete blood count (CBC)-adjusted hemoglobin A1c (HbA1c) model vs A1c-Derived Average Glucose (ADAG) formula for estimating CGM mean glucose
- Primary endpoint
- Association of CBC-derived measurements with the difference between HbA1c-estimated and CGM-estimated mean glycemia (eAGA1c - eAGCGM)
Primary result
As reported in the abstract
Association of CBC measurements with eAGA1c - eAGCGM (adjusted for age and sex)
- Platelet count and RBC distribution width (RDW) positively associated
- Hemoglobin, reticulocyte fraction, mean corpuscular volume (MCV), MCH, mean corpuscular hemoglobin concentration (MCHC) and reticulocyte MCHC negatively associated
Further findings
| Outcome | ADAG | CBCall-AGA1c |
|---|---|---|
| Estimation of eAGCGM, R2 | 0.68 (SD 0.07) | 0.72 (SD 0.06) |
Estimation of eAGCGM, R2
- CBCall-AGA1c gave modestly improved estimates of eAGCGM vs ADAG
Original publication
Differences Between Glycemia Estimates from Hemoglobin A1c and Continuous Glucose Monitoring and Their Association with Complete Blood Counts. Diabetes Technol Ther. Published 15 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →