Sleep quality in patients with non-functioning pituitary adenoma: impact of replacement therapies with an emphasis on the time of hydrocortisone
Authors' conclusion
Our study indicated the presence of depression, and a free T4 level in the upper half of the normal range have an impact on the sleep quality of patients with NFPA. The time of hydrocortisone replacement might be important factor for improved sleep quality in patients with secondary adrenal insufficiency.
Study context
- Population
- Patients with non-functioning pituitary adenoma and age- and gender-matched controls; Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS) and International Physical Activity Questionnaire (IPAQ) used
- Participants
- 82 vs 82
- Comparison
- Non-functioning pituitary adenoma (NFPA) vs matched controls
- NFPAn = 82
- Controln = 82reference
- Outcome
- Decreased sleep quality (PSQI)
Methodological detailsage- and gender-matched controls
- Age- and gender-matched controls
Main finding
As reported in the abstract
P = 0.005
Observational data: associations, not effects.
Further findings
Hydrocortisone replacement and sleep quality
- No relationship between presence of hydrocortisone replacement and sleep quality
- P > 0.05
PSQI vs morning hydrocortisone replacement time (secondary adrenal insufficiency)
- Correlation coefficient
- r=0.834, p<0.001
- Strong positive correlation
Diabetes insipidus in decreased vs preserved sleep quality
- Diabetes insipidus significantly higher with decreased sleep quality
- P = 0.01
PSQI vs IGF-1 in NFPA
- Correlation coefficient
- r=−0.259, p=0.01
- Negative correlation
Predictors of sleep quality in NFPA (multivariate logistic regression)
- Depression score and FT4 in upper half of normal limit influence sleep quality
Original publication
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