Skeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women
Authors' conclusion
These findings suggest that greater myosteatosis is associated with slower information processing speed, an early indicator of cognitive impairment. Further studies are needed to establish this association in this and other populations using an expanded battery of cognitive tests with longitudinal follow-up and to identify the biological mechanisms underlying this relationship.
Study context
- Population
- African Caribbean women aged 40 to 84 years, a population highly vulnerable to increased myosteatosis
- Participants
- 626 women
- Outcome
- Association of calf muscle density (CT-derived; higher = less myosteatosis) with DSST score (information processing speed)
Main finding
As reported in the abstract
DSST score per one-SD lower calf muscle density (CT-derived)
Lower Digit Symbol Substitution Test (DSST) score per one-SD lower muscle density (adjusted linear regression)
1.69-point lower
p = 0.002
Observational data: associations, not effects.
Further findings
- BMI, diabetes and hypertension interactions not statistically significant
Original publication
Skeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women. Obesity (Silver Spring). Published 20 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →