Diet-Related Lipidomic Signatures and Changed Type 2 Diabetes Risk in a Randomized Controlled Feeding Study With Mediterranean Diet and Traditional Chinese or Transitional Diets
Authors' conclusion
These fish- and red meat-related lipidomic signatures sensitively reflected different diets and modified type 2 diabetes risk factors, critical for optimizing dietary patterns.
Study context
- Population
- Chinese adults with overweight and prediabetes; lipid associations with habitual diet examined in a Chinese cohort (n = 1,117)cohort n = 1,117
- Participants
- 231 adults
- Comparison
- Mediterranean vs traditional Chinese vs transitional diet
Methodological detailsrandomized feeding trial, targeted lipidomics, February to September 2019
- Randomized feeding trial
- Targeted lipidomics
- February to September 2019
Primary result
As reported in the abstract
Diet-induced plasma lipidomic changes
- Lipidomic species altered across groups (out of 364)
- 26
- TAG fractions altered
- 12
- Plasmalogens altered
- nine
- Phosphatidylcholines (PCs) altered
- four
- Phosphatidylethanolamine altered
- one
Further findings
Association with habitual diet in cohort
- TAG fractions and PCs associated with habitual fish intake; plasmalogens with red meat intake
Matsuda index
- 10 TAG fractions and PC(16:0/22:6) associated with improved Matsuda index, β
- 0.12 to 0.42; PFDR < 0.030
Fasting glucose
- Two plasmalogens associated with deteriorated fasting glucose, β
- 0.29 to 0.31; PFDR < 0.014
- Similar results for TAG and plasmalogen related modules
Original publication
Diet-Related Lipidomic Signatures and Changed Type 2 Diabetes Risk in a Randomized Controlled Feeding Study With Mediterranean Diet and Traditional Chinese or Transitional Diets. Diabetes Care. Published 18 July 2023. doi:10.
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