Sex Steroid Levels in Women With Hypopituitarism: A Case-controlled Observational Study
Authors' conclusion
This study demonstrates for the first time a broad and severe sex steroid deficiency in both younger and older women with HH, particularly in those with combined gonadotropin and ACTH deficiency. The health impact of low sex steroid levels in women with hypopituitarism requires further study, and women with combined gonadotropin and ACTH deficiency should be a prioritized group for intervention studies with sex hormone replacement.
Study context
- Population
- Women with hypopituitarism who started GH replacement in 1995 to 2014 at a single center (n = 104)
- Exposure
- Women with hypopituitarism vs population-based controls
- Controlsn = 288reference
- Outcome
- Sex steroids (DHEA, androstenedione, testosterone, dihydrotestosterone, progesterone, 17αOH-progesterone, estradiol, estrone) by LC-MS/MS
Methodological detailssingle-centre, population-based controls
- Single-centre
- Population-based controls
Main finding
As reported in the abstract
Sex steroid levels
- Among premenopausal/younger and postmenopausal/older women, hypogonadotropic hypogonadism (HH) had lower sex steroid precursors (dehydroepiandrosterone (DHEA), androstenedione) and androgens (testosterone, dihydrotestosterone) than controls
- Progesterone, 17αOH-progesterone, estrone and estradiol showed similar patterns
Observational data: associations, not effects.
Further findings
- HH with ACTH deficiency had markedly lower concentrations of all sex hormones than those without ACTH deficiency
Original publication
Sex Steroid Levels in Women With Hypopituitarism: A Case-controlled Observational Study. J Clin Endocrinol Metab. Published 4 April 2024. doi:10.
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