Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls
Authors' conclusion
This study reveals heightened anxiety, alexithymia, depression, and diminished overall mental health in patients with AVP-D and PP. The results emphasize the need for careful interpretation of psychopathological characteristics to differentiate between AVP-D and PP.
Study context
- Population
- Patients with arginine vasopressin deficiency (AVP-D) or primary polydipsia (PP) and healthy controls
- Participants
- 82 patients2 studies
- Exposure
- AVP-D vs PP vs healthy controls
- AVP-Dn = 39
- PPn = 28
- Healthy controls (HC)n = 15reference
- Outcome
- Anxiety (State-Trait Anxiety Inventory (STAI)), points
Methodological detailsdata from two studies
- Data from two studies
Main finding
As reported in the abstract
AVP-D vs HC: P < 0.01 · AVP-D vs PP: P = 0.58
Observational data: associations, not effects.
Further findings
Alexithymia (TAS-20), points — AVP-D vs HC · higher alexithymia in AVP-D and PP vs HC
P < 0.01
| Outcome | AVP-D | PP | HC | P value |
|---|---|---|---|---|
| Alexithymia (TAS-20), pointsAVP-D vs PP · no difference | P = 0.90 | |||
| Depression (BDI-II), pointsAVP-D vs HC · higher depression in AVP-D and PP vs HC | 7 (range 4–14) points | 7 (range 3–13) points | 1 (range 0–2) point | P < 0.01 |
| Depression (BDI-II), pointsAVP-D vs PP · no difference | P = 0.50 | |||
| Overall mental health (SF-36)AVP-D vs HC · reduced in AVP-D | 60 (range 52–80) | 60 (range 47–74) | 84 (range 68–88) | P = 0.05 |
| Overall mental health (SF-36)PP vs HC · reduced in PP | P < 0.01 |
Original publication
Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia compared to healthy controls. Eur J Endocrinol. Published 29 March 2024. doi:10.
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