Sex-specific Trajectories of Insulin Resistance Markers and Reduced Renal Function During 18 Years of Follow-up: TLGS
Authors' conclusion
An increasing trend of HOMA-IR is associated with a higher risk of CKD in men and women. Among clinical IR surrogate markers, abnormal trajectory patterns of LAP in women and TyG and VAI in both sexes are associated with a higher risk of CKD.
Study context
- Population
- Participants aged ≥20 years, Tehran Lipid and Glucose Study, followed 18 years at 3-year intervals
- Participants
- 3,071 participants
- Exposure
- Insulin resistance (IR) marker trajectory classes
- Outcome
- Incident CKD
- Follow-up
- 18 years
Methodological detailslongitudinal, sex-specific trajectory analysis (latent variable mixture modeling), multivariable Cox proportional-hazards regression
- Longitudinal
- Sex-specific trajectory analysis (latent variable mixture modeling)
- Multivariable Cox proportional-hazards regression
Main finding
As reported in the abstract
Incident CKD by IR marker trajectory, by sex
Hazard ratio (95% CI)
Increasing HOMA-IRvs Stable HOMA-IRmen; adjusted
1.72(1.06–2.79)
Increasing HOMA-IRvs Stable HOMA-IRwomen; adjusted
1.37(1.00–1.89)
High TyGvs Low TyGmen
1.97(1.12–3.46)
High VAIvs Low VAImen
1.66(1.06–2.62)
High TyGvs Low TyGwomen
1.50(1.06–2.12)
High VAIvs Low VAIwomen
1.66(1.20–2.31)
High LAPwomen
3.38(2.08–5.48)
Observational data: associations, not effects.
Original publication
Sex-specific Trajectories of Insulin Resistance Markers and Reduced Renal Function During 18 Years of Follow-up: TLGS. J Clin Endocrinol Metab. Published 22 December 2022. doi:10.
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