Sex-specific differences in myocardial glucose metabolic rate in non-diabetic, pre-diabetic and type 2 diabetic subjects
Authors' conclusion
Our data suggest that deterioration of glucose homeostasis in women is associated with a greater impairment in myocardial glucose metabolism as compared with men. The sex-specific myocardial insulin resistance could be an important factor responsible for the greater effect of T2DM on the excess risk of cardiovascular disease in women than in men.
Study context
- Population
- Non-diabetic, prediabetic and T2D subjects (women and men)
- Participants
- 20 / 11 / 26
- Exposure
- Myocardial MRGlu by glucose tolerance status, women vs men
- Normal glucose tolerance (NGT)n = 20reference
- Prediabetesn = 11
- T2DMn = 26
- Outcome
- Sex-related differences in myocardial glucose metabolic rate (MRGlu)
Methodological detailsdynamic PET with 18F-FDG combined with euglycemic-hyperinsulinemic clamp
- Dynamic PET with 18F-FDG combined with euglycemic-hyperinsulinemic clamp
Main finding
As reported in the abstract
Myocardial MRGlu, age-adjusted, vs same-sex NGT
Women with prediabetes vs women with NGT: lower myocardial MRGlu (P = 0.04)
35%
Women with T2DM vs women with NGT: lower myocardial MRGlu (P = 0.006)
74%
Men with T2DM vs men with NGT: lower myocardial MRGlu (P = 0.004)
40%
Observational data: associations, not effects.
Original publication
Sex-specific differences in myocardial glucose metabolic rate in non-diabetic, pre-diabetic and type 2 diabetic subjects. Cardiovasc Diabetol. Published 26 April 2024. doi:10.
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