Sex‐specific associations between skeletal muscle mass and incident diabetes: A population‐based cohort study
Authors' conclusion
In females, a larger muscular mass is associated with a lower risk of type 2 diabetes. For males, this association is significant only among those with diminished muscle mass.
Study context
- Population
- Chinese adults without diabetes at baseline from WATCH (West chinA adulT health CoHort), a health check-up-based database; median age 40 years, 53.2% women1,836 developed T2D
- Participants
- 47,885 adults
- Exposure
- Higher vs lower predicted skeletal muscle mass index, by sex
- Outcome
- Incident T2D
- Follow-up
- 5-year median
Methodological detailspopulation-based, longitudinal, sex-specific analysis, weighted Cox proportional hazards regression with segmented linear splines
- Population-based
- Longitudinal
- Sex-specific analysis
- Weighted Cox proportional hazards regression with segmented linear splines
Main finding
As reported in the abstract
Estimate (95% CI)P value
Womenhigher pSMI associated with lower risk
HR per SD increment in pSMI 0.79(0.68–0.91)
Pnonlinearity = 0.09Men, pSMI <8.1higher pSMI associated with lower risk
HR 0.58(0.40–0.84)
Men, pSMI ≥8.1not significantly associated
HR 1.08(0.93–1.25)
- Nonlinear association of pSMI with incident T2D in men
- Pnonlinearity < 0.001
Observational data: associations, not effects.
Original publication
Sex‐specific associations between skeletal muscle mass and incident diabetes: A population‐based cohort study. Diabetes Obes Metab. Published 23 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →