Development of a New Model of Insulin Sensitivity in Patients With Type 2 Diabetes and Association With Mortality
Authors' conclusion
We propose a new model of IS in patients with T2D based on readily available clinical and laboratory data. Its potential applications are in both diagnosis as well as prognostication.
Study context
- Population
- Patients with T2D: 140 with euglycemic hyperinsulinemic clamp; 3553 from National Health and Nutrition Examination Survey (NHANES) 1999–2010clamp cohort
- Participants
- 140 patients
- Outcome
- Model of insulin sensitivity from clinical and laboratory parameters vs clamp-derived glucose disposal rate; association with all-cause and cardiovascular mortality
Methodological detailseuglycemic hyperinsulinemic clamp, stepwise linear regression, training and validation cohorts, multivariable Cox proportional hazard model
- Euglycemic hyperinsulinemic clamp
- Stepwise linear regression
- Training and validation cohorts
- Multivariable Cox proportional hazard model
Performance
As reported in the abstract
IS score correlation with clamp-derived glucose disposal rate
| Test or model | Value | P |
|---|---|---|
| Training | r 0.77 | P < .001 |
| Validation | r 0.74 | P < .001 |
Value
Trainingr 0.77
Validationr 0.74
P
TrainingP < .001
ValidationP < .001
Further findings
All-cause and cardiovascular mortality, NHANES cohort · median follow-up 8.3 years
- Deaths
- 1054
- Cardiovascular deaths
- 265
- Higher estimated insulin sensitivity (IS) associated with lower risk of all-cause and cardiovascular mortality
- Multivariable Cox model adjusted for age, sex, race-ethnicity, education, smoking, total cholesterol, CKD, blood pressure, prevalent CVD and alcohol consumption
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Development of a New Model of Insulin Sensitivity in Patients With Type 2 Diabetes and Association With Mortality. J Clin Endocrinol Metab. Published 22 November 2023. doi:10.
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