Sex-related differences of diabetic cardiomyopathy
Authors' conclusion
These findings highlight distinct sex-specific mechanisms of microvascular dysfunction and myocardial remodeling in T2D. Recognizing these differences may be critical for improving risk stratification and guiding targeted preventive strategies in diabetic cardiomyopathy.
Study context
- Population
- Patients with T2D without ischemic heart disease and age-matched controls221 T2D, 25 controls
- Exposure
- Women vs men with T2D; T2D vs healthy controls
- Controlsn = 25reference
- Outcome
- Sex differences in MBFrest, MBFstress and ECV
Methodological detailsechocardiography and cardiovascular magnetic resonance imaging, age-matched controls
- Echocardiography and cardiovascular magnetic resonance imaging
- Age-matched controls
Main finding
As reported in the abstract
- Women with T2D had higher MBFrest, MBFstress and ECV than men, in unadjusted and confounder-adjusted analyses
- Multiple linear regression adjusted for known confounders
Observational data: associations, not effects.
Further findings
Myocardial perfusion reserve (MPR)
- T2D men and women both had lower MPR vs healthy controls, with differing underlying causes
Diastolic function
- Female sex associated with lower lateral e' and higher E/e' independently of MBFstress and ECV
Original publication
Sex-related differences of diabetic cardiomyopathy. Diabetes Res Clin Pract. Published 23 September 2025. doi:10.
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