Sex inequalities in cardiovascular risk factors and their management in primary prevention in adults living with type 1 diabetes in Germany and France: findings from DPV and SFDT1
Authors' conclusion
In both studies, females in primary prevention have a better cardiovascular risk profile than males. We observed a high rate of therapeutic inertia, which might be higher in females for statin treatment and nephroprotection with ACEi-ARB, especially in Germany. Diabetologists should be aware of sex-specific differences in the management of cardiorenal risk factors to develop more personalized prevention strategies.
Study context
- Population
- Adults with T1D without cardiovascular history, DPV centres (Germany) and SFDT1 cohort (France), 2020–2022DPV 2,657
- Exposure
- Females vs males with T1D
- Outcome
- Sex differences in cardiovascular risk factors and their management in primary prevention, and achievement of standards of care
Methodological detailstwo European cohorts (DPV registry, Germany; SFDT1 cohort, France), primary prevention (no cardiovascular history)
- Two European cohorts (DPV registry, Germany; SFDT1 cohort, France)
- Primary prevention (no cardiovascular history)
Main finding
As reported in the abstract
2020-2022
- BMI similar in females and males
- Systolic BP lower in females than males
- HDL-C higher and TG lower in females in both countries
- Females vs Males: P = 0.06
- Females vs Males: P = 0.41
- Females vs Males: P < 0.01
- Females vs Males: P = 0.33
- Females vs Males: P < 0.01
- Females vs Males: P = 0.07
- Females vs Males: P = 0.02
- Females vs Males: P = 0.64
- Females vs Males: P < 0.01
- Females vs Males: P = 0.01
- Females vs Males: P = 0.43
- Females vs Males: P < 0.01
- Females vs Males: P = 0.42
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex inequalities in cardiovascular risk factors and their management in primary prevention in adults living with type 1 diabetes in Germany and France: findings from DPV and SFDT1. Cardiovasc Diabetol. Published 16 September 2024. doi:10.
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