Is the Current Screening Availability for Early Stages of Type 1 Diabetes in Germany Related to the Population‐Based Frequency of Diabetic Ketoacidosis at Clinical Manifestation in Children and Adolescents
Main finding · DKA at manifestationResult — go to the resultRelative risk 0.96 95% CI 0.93–1.03Authors' conclusion
Until 2023, current regional screening initiatives for early-stage T1D were not associated with lower frequency of DKA at population level, but might be helpful in the future if the coverage can be markedly increased.
Study context
- Population
- Children aged 0.5 to <15 years with T1D manifestation in 2015–2023 in Germany, DPV registry, allocated to federal states by residential postal code; 54.3% males, median onset age 8.8 years
- Participants
- 24,408 children
- Exposure
- Federal states with vs without screening for early-stage T1D
- Outcome
- DKA at T1D manifestation
Methodological detailsmulticenter registry (DPV), logistic regression
- Multicenter registry (DPV)
- Logistic regression
Main finding
DKA at manifestation
Relative risk
0.96
95% CI 0.93–1.03
P = 0.393
FS with screeningvs FS without screening
RR 0.96 (95% CI 0.93–1.03); P = 0.393
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| DKA at manifestation, subgroup with highest probability of being screened (age 1.75-10.99 years, manifestation in Bavaria 2020-2023) | 0.88 (0.80–0.97) | P = 0.012 | |
| 0.512Relative risk (log scale) |
Predictor of diabetic ketoacidosis (DKA): manifestation age <3 years
- RR for DKA with manifestation age <3 years (most important predictor), [1.66-2.03], p < 0.001
- 1.83
Original publication
Is the Current Screening Availability for Early Stages of Type 1 Diabetes in Germany Related to the Population‐Based Frequency of Diabetic Ketoacidosis at Clinical Manifestation in Children and Adolescents. Pediatr Diabetes. Published 8 February 2026. doi:10.
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