Sex Differences in Risk for Iatrogenic Thyrotoxicosis Among Older Adults: An Analysis from Real-World Clinical Data
Authors' conclusion
Mediation analysis demonstrates that the increased risk of iatrogenic thyrotoxicosis in older women may be attributable to differences in body composition between men and women.
Study context
- Population
- Adults age 50 and older on thyroid hormone, large community health system in the United States; 77% female, 23% non-White
- Participants
- 20,724 participants
- Exposure
- Women vs men
- Outcome
- Iatrogenic thyrotoxicosis (low TSH)
Methodological detailselectronic health records, large community health system, mediation analysis
- Electronic health records
- Large community health system
- Mediation analysis
Main finding
As reported in the abstract
Low TSH (iatrogenic thyrotoxicosis)
Female vs MaleEstimate (95% CI)P value
Low TSH (iatrogenic thyrotoxicosis)
unadjusted HR 1.67(1.56–1.79)
Pvs models not accounting for dose
HR, fully adjusted incl. dose per actual body mass 1.50(1.34–1.69)
P = 0.422Partially mediated
HR, adjusted for dose per ideal body mass 1.30(1.16–1.46)
P < 0.001Fully mediated
HR, adjusted for dose per lean body mass 1.06(0.95–1.19)
P < 0.001Observational data: associations, not effects.
Further findings
Median daily levothyroxine dose per actual body mass
P < 0.001
Original publication
Sex Differences in Risk for Iatrogenic Thyrotoxicosis Among Older Adults: An Analysis from Real-World Clinical Data. Thyroid. Published 21 March 2025. doi:10.
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