Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study
Authors' conclusion
This study indicates that there are sex differences in body composition associated with type 2 diabetes. The pathophysiological significance of these sex-associated differences requires further study.
Study context
- Population
- Adults aged 40–75 years, 50% women, 25% T2D; the Maastricht Study
- Participants
- 7,639 adults
- Exposure
- Prediabetes and T2D vs normal glucose metabolism, by sex
- Outcome
- Sex differences (women minus men) in DEXA- and MRI-derived body composition and hip circumference associated with diabetes status
Methodological detailscross-sectional analysis of sex-by-diabetes status interaction, adjusted regression models
- Cross-sectional analysis of sex-by-diabetes status interaction
- Adjusted regression models
Main finding
As reported in the abstract
Sex difference (W-M) in T2D vs NGM difference in body composition
Women vs MenMean difference, cm2 (95% CI)
Subcutaneous adipose tissue; T2Dvs NGM difference greater in women
15.0(1.5–28.5)
Visceral adipose tissue; greater in men
−14.8(−26.4 to −3.1)
Women vs MenMean difference, cm (95% CI)
Hip circumference; greater in women
3.2(2.2–4.1)
Women vs MenMean difference, g (95% CI)
Total lean mass; greater in women
690(8–1372)
Peripheral lean mass; greater in women
443(142–744)
Observational data: associations, not effects.
Further findings
Sex differences in body composition, prediabetes vs NGM
- Generally in the same direction, but not significantly different between women and men
Original publication
Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study. Diabetologia. Published 20 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →