Serum vs. exosomal miRNA signatures in South Asian adults with prediabetes: implications for T2DM risk prediction
Authors' conclusion
Our findings indicate that analysis of total serum miRNAs provides a more sensitive and robust approach for identifying individuals with prediabetes, which correlates with the exosomal fraction.
Study context
- Population
- South Asian adults with prediabetes, newly diagnosed or persisting T2DM, and matched normoglycemic controlspaired serum and exosomes
- Participants
- 25 / 15 / 25 / 25
- Exposure
- Serum vs exosomal miRNA expression across prediabetes, newly diagnosed T2DM, persisting T2DM and normoglycemic controls
- Prediabetesn = 25
- n-T2DMn = 15
- Persisting T2DMn = 25
- Normoglycemic controlsn = 25reference
- Outcome
- Serum and exosomal miRNA expression (miR-128-3p, miR-15b-5p, miR-6838-5p, miR-195-5p, miR-424-5p) by RT-qPCR
Methodological detailsage-, sex-, and BMI-matched controls
- Age-, sex-, and BMI-matched controls
Main finding
As reported in the abstract
- Distinct miRNA signatures in whole serum and exosomal fractions
- miR-195-5p and miR-6838-5p consistently and significantly upregulated in prediabetes
- Exosomal miRNAs showed distinct changes in both prediabetes and n-T2DM
Observational data: associations, not effects.
Further findings
Diagnostic performance (ROC analysis), prediabetes vs normoglycemia
- Significant ability to differentiate prediabetes from normoglycemia
Original publication
Serum vs. exosomal miRNA signatures in South Asian adults with prediabetes: implications for T2DM risk prediction. Diabetes Res Clin Pract. Published 17 July 2026. doi:10.
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