IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled Analysis of Prospective Cohort Studies
Authors' conclusion
IgG N-glycosylation may reflect immune-related mechanisms relevant to diabetic nephropathy; but the evidence between IgG-GPs and diabetic neuropathy remains inconclusive.
Study context
- Population
- Individuals with and without T2D at IgG N-glycosylation profiling, cohorts EPIC-Potsdam, DiaGene, GenoDiabMar and Hoorn DCS
- Participants
- 3,263 individuals4 cohorts
- Comparison
- IgG N-glycan peaks (IgG-GPs) and traits and incident diabetic nephropathy and neuropathy
- Outcome
- Incident diabetic nephropathy and neuropathy after diabetes diagnosis
Methodological detailsfour cohorts, Cox models, meta-analyzed across cohorts
- Four cohorts
- Cox models
- Meta-analyzed across cohorts
Pooled result
As reported in the abstract
Incident nephropathy
Agalactosylated, asialylated and bisected IgG-GPs associated with higher nephropathy risk; IgG-GP3 HR
1.13 (1.04-1.24) (95% CI)
IgG-GP4 HR
1.15 (1.05-1.26) (95% CI)
Galactosylated and sialylated IgG-GPs associated with lower risk; IgG-GP14 HR
0.86 (0.78-0.94) (95% CI)
IgG-GP18 HR
0.85 (0.77-0.94) (95% CI)
Original publication
IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled Analysis of Prospective Cohort Studies. Diabetes Care. Published 17 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →