Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
Authors' conclusion
Our findings indicate that the effects of dietary fat quality on the lipidome can contribute to a more precise understanding and possible prediction of the health outcomes of specific dietary fat modifications.
Study context
- Population
- EPIC-Potsdam cohort; Nurses' Health Study; PREDIMED trial participants
- Comparison
- Higher vs lower multilipid score reflecting better dietary fat quality
Methodological detailsmultilipid score derived from RCT lipidomics, validation in EPIC-Potsdam cohort, Nurses' Health Study and PREDIMED trial
- Multilipid score derived from RCT lipidomics
- Validation in EPIC-Potsdam cohort, Nurses' Health Study and PREDIMED trial
Primary result
As reported in the abstract
CVD incidence reduction with multilipid score (MLS) difference reflecting better dietary fat quality
−32%
95% CI −21% to −42%
T2D incidence reduction with MLS difference reflecting better dietary fat quality
−26%
95% CI −15% to −35%
Further findings
| Outcome | OR per SD (95% CI) | |
|---|---|---|
| Diabetes risk per SD beneficial rMLS change over 10 years (Nurses' Health Study) | 0.76 (0.59–0.98) | |
| 0.512Odds ratio per SD (log scale) |
Diabetes incidence with olive oil-rich Mediterranean diet by preintervention reduced MLS (rMLS) (PREDIMED)
- Intervention primarily reduced diabetes incidence among participants with unfavorable preintervention rMLS levels
Original publication
Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition. Nat Med. Published 11 July 2024. doi:10.
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