Serum levels of the incretin‐like peptide 26RFa are diminished in women living with obesity and diabetes and restored after sleeve gastrectomy: Results from the prospective pilot RFa ‐Ba‐S study
Authors' conclusion
This prospective clinical study provides the first evidence that circulating 26RFa is altered mainly in WlwOB-T2D, and that these defects are partially reversed after SG.
Study context
- Population
- Women living with obesity with or without T2D undergoing sleeve gastrectomy (SG), and lean healthy volunteers
- Participants
- 61 women
- Exposure
- Women with severe obesity with or without T2D before and after SG vs lean healthy controls
- Outcome
- Serum 26RFa concentrations during meal tests
- Follow-up
- Before SG, and 30 and 180 days after SG
Methodological detailspilot
- Pilot
Main finding
As reported in the abstract
Serum 26RFa levels
- Fasting 26RFa increased in WlwOB-T2D throughout follow-up up to 6 months after SG
- P < .001
Observational data: associations, not effects.
Original publication
Serum levels of the incretin‐like peptide 26RFa are diminished in women living with obesity and diabetes and restored after sleeve gastrectomy: Results from the prospective pilot RFa ‐Ba‐S study. Diabetes Obes Metab. Published 30 September 2024. doi:10.
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