Fructose intake, endogenous biomarkers and latent metabolic construct in adolescents: Exploring path associations and mediating effects
Authors' conclusion
UA and HOMA-IR individually and jointly mediate the adverse effects of high fructose-rich SSB intake on the mechanisms underlying paediatric MetS. Fructose-free tea-based beverages may have a beneficial effect on latent MetS structure in adolescents.
Study context
- Population
- Adolescents in a population-based representative cohort evaluated for metabolic syndrome (MetS) risk profiles
- Participants
- 1,454 adolescents
- Outcome
- Mediating effects of UA and HOMA-IR on fructose-rich tea beverage (FTB) intake >500 mL/day and latent MetS construct (MetsC)
Methodological detailspopulation-based representative cohort, structural equation modelling, mediation analysis
- Population-based representative cohort
- Structural equation modelling
- Mediation analysis
Main finding
As reported in the abstract
- FTB → uric acid (UA) → MetS construct (MetsC): adjusted standardized coefficient; mediating effect
- 0.071; 23.1%
- FTB → homeostatic model assessment of insulin resistance (HOMA-IR) → MetsC: adjusted standardized coefficient; mediating effect
- 0.034; 11.0%
- FTB → UA → HOMA-IR → MetsC: adjusted standardized coefficient; mediating effect
- 0.010; 3.1%
- UA-associated pathways' share of overall mediation (bottled sugar-containing beverage intake and MetsC)
- 31.1%
- Tea-related beneficial effect of FTB >500 mL/day on MetsC after accounting for UA- and HOMA-IR-derived effects: adjusted standardized coefficient
- −0.103
Observational data: associations, not effects.
Original publication
Fructose intake, endogenous biomarkers and latent metabolic construct in adolescents: Exploring path associations and mediating effects. Pediatr Obes. Published 28 September 2024. doi:10.
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