Serum Dehydroepiandrosterone (DHEA) and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
Authors' conclusion
Serum levels of DHEA and testosterone are inversely associated with CAC in elderly men, partially independently from each other. These results raise the question whether androgens from both the adrenals and the testes may contribute to male cardiovascular health.
Study context
- Population
- Men from the population-based AGES-Reykjavik study, mean 76 years
- Participants
- 1,287 men
- Outcome
- Cross-sectional associations between DHEA, androstenedione, estrone, testosterone, dihydrotestosterone and estradiol and quintiles of CAC
Methodological detailspopulation-based, Sex steroids measured by gas chromatography tandem mass spectrometry; Coronary artery calcification (CAC) score by CT
- Population-based
- Sex steroids measured by gas chromatography tandem mass spectrometry; CAC score by CT
Main finding
As reported in the abstract
Association of serum sex steroids with CAC
- DHEA, androstenedione, testosterone, dihydrotestosterone and bioavailable testosterone showed significant inverse associations with CAC
- Estrone, estradiol, bioavailable estradiol and sex hormone-binding globulin (SHBG) were not associated with CAC
Observational data: associations, not effects.
Further findings
Association with CAC after adjustment for traditional CV risk factors
- DHEA, testosterone and bioavailable testosterone remained associated with CAC
- Partially independent associations of adrenal-derived DHEA and testes-derived testosterone with CAC
Original publication
Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men. J Clin Endocrinol Metab. Published 12 June 2023. doi:10.
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