Associations Between Fatigue and Endocrine and Non-endocrine Health Problems in Turner Syndrome: Cohort Study and Review
Authors' conclusion
There was no association between fatigue and most endocrine and non-endocrine disorders, which implies that fatigue is only partly explained by somatic disorders. The high correlation between perceived stress and fatigue suggests that TS-related neuropsychological processes may play an important role in the etiology of fatigue in women with TS. We provide a practical algorithm for the endocrine, non-endocrine, and psychological approach to fatigue in women with TS.
Study context
- Population
- Genetically confirmed women with turner syndrome (TS) attending the TS Reference Center; median (IQR) age 32.6 (23.9–41.4) years
- Participants
- 170 participants
- Outcome
- Association between fatigue and endocrine and non-endocrine comorbidities
Methodological detailssingle-centre (TS Reference Center), systematic health screening
- Single-centre (TS Reference Center)
- Systematic health screening
Main finding
As reported in the abstract
Severe fatigue
1 in 3 women with TS
Observational data: associations, not effects.
Original publication
Associations Between Fatigue and Endocrine and Non-endocrine Health Problems in Turner Syndrome: Cohort Study and Review. J Clin Endocrinol Metab. Published 10 June 2023. doi:10.
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