Growth During Pubertal Induction in Girls With Turner Syndrome: A Retrospective Cohort Analysis
Authors' conclusion
Decisions around timing of pubertal induction in patients with TS should be tailored to the individual. The current approach to estrogen supplementation needs to be refined in order to facilitate pubertal induction in a physiological manner without compromising height.
Study context
- Population
- Patients with Turner syndrome (TS) attending a specialised TS clinic at a quaternary children's hospital, 2015–2021; 51 received estradiol for pubertal induction51 received estradiol
- Participants
- 107 patients
- Outcome
- Change in height SDS (ΔHeightSDS) during pubertal induction and adult height (AH)
Methodological detailssingle specialised TS clinic, quaternary children's hospital
- Single specialised TS clinic
- Quaternary children's hospital
Main finding
As reported in the abstract
- Adult height (AH) predicted by mid-parental height (MPH)
- 0.8 cm/cm, P = .0001
- AH predicted by bone age delay
- −1.84 cm/year, P = .006
- ΔHeightSDS predicted by GH dose
- 0.09 SDS/mg/m²/week; P = .017
- ΔHeightSDS predicted by bone age delay
- −1.37 SDS/year; P = .003
- ΔHeightSDS predicted by age at pubertal induction
- 0.44 SDS/year; P = .001
- Interaction between bone age delay and pubertal induction age; younger induction age with less-delayed bone age associated with lower ΔHeightSDS
- P = .013
Observational data: associations, not effects.
Further findings
- Karyotype affected rates of other comorbidities
Original publication
Growth During Pubertal Induction in Girls With Turner Syndrome: A Retrospective Cohort Analysis. J Clin Endocrinol Metab. Published 9 February 2024. doi:10.
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